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“Our intention is to be aware of woman reproductive getting older, and why fertility quickly declines setting up during the mid-30s,” suggests Satoshi Namekawa, a professor of Microbiology and Molecular Genetics, in whose lab Munakata operates.
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Utilizing the GCRLE grant, Munakata and Namekawa will glance extra intently at how oocytes are genomically primed and saved for afterwards use. They're going to examine the job of a chromatin remodeler in oocyte survival and fertility.
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This protein may possibly “build and maintain the chromatin state,” says Namekawa — holding the spools in place along with the oocytes genetically primed given that the mouse matures.
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